The advances in genomics, informatics and analytics provides a possibility for more personalised and targeted treatments and in 2012, the UK announced its 100,000 Genomes Project. 

This groundbreaking project aimed to sequence 100,000 whole genomes from around 70,000 participants with rare disease, their families and people with some cancers

In 2016, as part of the aim to develop the 100,000 Genomes Project into a UK-wide initiative, Genomics England invited the Welsh Government to join the 100,000 Genomes Project.

The 100,000 Genomes Project in Wales will be used as an exemplar towards the integration of genomic medicine into clinical care pathways in Wales and aligns with the Welsh Government Genomics for Precision Medicine Strategy.